Web4 Jun 2024 · SPOP mutations define a distinct molecular class of PCa, with a high frequency of characteristic genomic rearrangements, but they are mutually exclusive with rearrangement between TMPRSS2 and the ETS family of transcription factors (mainly TMPRSS2:ERG) [ 2, 7 ]. Figure 1. Web25 Sep 2010 · SPOP: A Service Provider Oriented Peer-to-peer architecture Abstract:BitTorrent occupies actually a dominant part of the Internet traffic for various applications. The protocol provides an efficient transport level but is devoid of real management and control layers.
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Web5 Nov 2024 · A certified management professional with 20 plus years of both start-up and Fortune 100 experience and proven successes in managing very large, multi-year programs in the insurance, financial,... WebSPOP is frequently mutated or has altered expression in various cancers, including prostate, renal and endometrial. SPOP is involved in the regulation of proteasome-mediated degradation of several oncoproteins. Moreover, recent data also indicate SPOP's direct involvement in the DNA damage response. face fit train the trainer near me
Intrinsically disordered substrates dictate SPOP subnuclear ...
Web27 Oct 2015 · The SPOP protein targets various substrate proteins for degradation by adding a ubiquitin tag onto them. Known substrates of SPOP include the androgen receptor, the steroid co-activator SRC-3, and the DEK and ERG oncogenes. All of these targets may affect the aggressiveness of prostate cancer. Web4 Nov 2024 · SPOP Is a Direct Substrate of AURKA and They Interact with Each Other in CRPC Cells We generated 6x-His-tagged SPOP and subjected it to an in vitro phosphorylation assay with AURKA/TPX2. SPOP showed robust phosphorylation, validating it as a direct target of AURKA ( Figure 1 A, middle lane). WebA port-powered, two-channel isolator with a 2,500 Volts protection. It optically isolates both the RS-232 Transmit Data and Receive Data lines and RS-232 equipment from lightning surges, accidental high voltage shorts, and ground loops. RS-232 data signals TD and RD are supported up to 115.2 kbps. face fit train the trainer kent