Shoc2 and normal function
Web16 Oct 2024 · MO knockdown of shoc2. To explore the function of Shoc2 during embryogenesis, we first used two different translation-blocking morpholino antisense (MO) oligonucleotides to inhibit expression of shoc2 at early stages of development ().The effectiveness of gene knockdown by these translation-blocking MOs was confirmed by …
Shoc2 and normal function
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Web8 Jul 2024 · Young et al. (2024) showed that MRAS and SHOC2 function as PP1 regulatory subunits, providing the complex with striking specificity against RAF. MRAS also … WebClinical studies have also investigated the association between obesity and PCa. 26 Examining tumour and benign tissue in overweight and normal weight men with PCa, nearly 95% of whom had localised disease, 15 gene sets were found to be overexpressed in obese men, 5 of which functioned for chromatin modification and remodelling, which are linked …
WebSHOC2 (soc-2 suppressor of clear homolog) (eg, Noonan-like syndromewith loose anagen hair), S2G variant 81400-32 81400-33 SMN1 (survival of motor neuron 1, telomeric) (eg, spinal muscularatrophy), exon 7 deletion 81400-34 81400-35 81401-01 81401-03 81401-05 WebExplore 30 research articles published by the author Alma L. Burlingame from University of California, San Francisco in the year 2013. The author has contributed to research in topic(s): Mass spectrometry & Phosphorylation. The author has an hindex of 107, co-authored 610 publication(s) receiving 43486 citation(s). Previous affiliations of Alma L. …
Webassay was recruited to validate whether SHOC2 was a downstream target of miR-299-3p. In ad-dition, the protein expression SHOC2 in trans- ... MiR-299-3p functions as a tumor suppressor in thyroid cancer by regulating SHOC2. ... and one normal human thyroid cell line Nthy-ori3-1 were obtained from Cell Bank of Chinese Academy of Sciences (Shang ... Web24 Mar 2024 · SHOC2 is a prototypical leucine-rich repeat protein that promotes downstream receptor tyrosine kinase (RTK)/RAS signaling and plays important roles in …
Websupporting a large number of cellular functions. In this review, we summa-rize recent advancements in understanding functions of the LRR proteins as signaling scaffolds. In particular, we explore what we have learned about the mechanisms of action of the LRR scaffolds Shoc2 and Erbin and their roles in normal development and disease. We …
Web12 Mar 2024 · SHOC2 mutations were found in lung cancer tissues with gain-of-function activity. Collectively, the SHOC2-Raptor interaction triggers negative cross-talk between RAS-ERK and mTORC1 pathways, whereas FBXW7 regulates both pathways by targeting SHOC2 for ubiquitylation and degradation. ... (2%), normal serum (10%) or EGF addition, ectopic … terminate pty ltdWebFull gene name according to HGNC. SHOC2 leucine rich repeat scaffold protein. Gene namei. Official gene symbol, which is typically a short form of the gene name, according to … terminate pthreadWeb9 Dec 2024 · SHOC2 is a scaffold protein comprising an N-terminal lysine-rich region and subsequent 19 leucine-rich repeats (LRRs) that plays a crucial role in the activation of the ERK1 (MAPK3; 601795 )/ERK2 (MAPK1; 176948) signaling pathway ( Cordeddu et al., 2009; Rodriguez-Viciana et al., 2006; Matsunaga-Udagawa et al., 2010 ). terminateprocess hprocess 0WebThis gene encodes a protein that consists almost entirely of leucine-rich repeats, a domain implicated in protein-protein interactions. The protein may function as a scaffold linking RAS to downstream signal transducers in the RAS/ERK MAP kinase signaling cascade. Mutations in this gene have been associated with Noonan-like syndrome with loose anagen hair. trichy infotechWeb24 Mar 2024 · Gain-of-function mutations of NRAS gene are causally related to NS type 6. Thus, it is conceivable that NRAS haploinsufficiency and gain-of-function mutations may have similar clinical consequences. The same phenomenon has been described for two other genes belonging to the Ras/MAPK pathway: MAP2K2 and SHOC2. terminate process powershellWeb7 Aug 2024 · Looking in detail at the cellular role of SHOC2, the group identified both SHOC2-dependent and -independent mechanisms of ERK activation. Importantly, … terminate process pythonWebNoonan and Noonan-related syndromes are common autosomal dominant disorders with neuro-cardio-facial-cutaneous and developmental involvement. The objective of this article is to describe the most relevant tegumentary findings in a cohort of 41 trichy images