Web8 mrt. 2024 · protein-2 associated kinase 1 (AAK1) is a viable target for treating neuropathic pain, as first demonstrated in the mouse knockout phenotype.16 AAK1 belongs to the class of numb-associated family of protein kinases (NAKs), which include BMP-2-inducible kinase (BIKE/BMP2K) and cyclin G-associated kinase (GAK) among … Web1 mrt. 2016 · The Numb-associated family of protein kinases (NAKs) constitute a diverse family in terms of Ser/Thr kinases in both their function and structure, sharing little conservation outside of the kinase domain (Smythe and Ayscough, 2003) and as low as 30% sequence identity across their kinase domains.
Use of Janus kinase inhibitors in COVID-19: a prospective …
Web20 mei 2024 · Numb is a multifunction adaptor protein that is expressed in renal tubules. The aim of the present study was to evaluate the role of Numb in mitochondrial dysfunction during AKI. Results: Depletion of Numb from proximal tubules (PT-Nb-KO) exacerbated AKI shown as more severe renal tubular damage and higher serum creatinine than wild-type … Web5 feb. 2024 · This kinase has been shown to play an important role in regulating the clathrin-mediated endocytosis of the rabies virus, facilitating infection. Inhibitors of this … pearhead faire
The cargo adapter protein CLINT1 is phosphorylated by the Numb ...
Web1 aug. 2024 · The Numb-associated kinases family of Ser/Thr kinases is composed of adaptor-associated kinase 1 (AAK1), BMP-2 inducible kinase (BIKE/BMP2K), cyclin G-associated kinase (GAK), and serine/threonine kinase 16 (STK16). These kinases share only limited homology in their kinase domain and low homology in other protein regions … Web3 mrt. 2024 · Human protein Ser/Thr kinases Adaptor protein 2-Associated Kinase 1 (AAK1) and BMP-2-Inducible Kinase (BMP2K/BIKE) play critical roles in mediating endocytosis and other key signaling pathways. Both are broadly expressed members of the NAK family of human kinases, which also includes Cyclin G-Associated Kinase (GAK) … WebNUMB, a plasma membrane-associated protein originally described in Drosophila, is involved in determining cell function and fate during early stages of development. It is secreted... pearhead ceramic piggy bank