Mitf phosphorylation
Web3 okt. 2024 · ERK activation induces phosphorylation of MITF at serine 73, leading to its ubiquitination, followed by proteasome-mediated degradation. Moreover, sustained activation of ERK by C2 ceramide and sphingosine-1-phosphate (S1P) is reported to trigger MITF phosphorylation and subsequent degradation, resulting in reduced tyrosinase … WebInvitrogen Anti-Phospho-MiTF (Ser516) Polyclonal, Catalog # PA5-105415. Tested in Western Blot (WB) and Immunohistochemistry (Paraffin) (IHC (P)) applications. This …
Mitf phosphorylation
Did you know?
Web26 dec. 2024 · Previous studies showed that the phosphorylation of ERKs, JNKs, p38, Akt, and S6K upregulated MITF translocation and tyrosinase expression in α-MSH-stimulated B16F10 cells. Therefore, we assume that phosphorylation levels of ERKs, JNKs, p38, Akt, and S6K may be more important for α-MSH-induced melanogenesis. WebMITF AKT Phosphorylation TP53 Senescence a b s t r a c t Microphthalmia-associated transcription factor (MITF) plays a crucial role in the melanogenesis and proliferation of melanocytes that is dependent on its abundance and modification. Here, we report that epidermal growth factor (EGF) induces senescence and cyclin-dependent kinase ...
Web21 feb. 2001 · Loss of phosphorylation and function. 1 publication. Sequence: S → A or P: Mutagenesis: 423: Loss of sumoylation; when associated with R-289. 1 publication. ... 293822 MITF-related melanoma and renal cell carcinoma predisposition syndrome; 319298 Papillary renal cell carcinoma; 42665 Tietz syndrome; More Orphanet links; PharmGKB. Web1 okt. 2009 · It is shown that mice that carry a BAC transgene where single-amino-acid substitutions have been made in the Mitf gene rescue the phenotype of the loss-of …
Web6 nov. 2024 · HIP1R, PKCα/GSK3β/MITF, ADAM10/17, and endosomal sorting-signal induce PD-L1 protein degradation by autophagy, ... cyclinD-CDK4 mainly induced SPOP phosphorylation at serine-6, ... Web23 mrt. 2011 · The results showed that p-MITF was significantly elevated in the UV group compared with other groups (P < 0.05). We gather from this result that nitric oxide was …
Web15 mei 2024 · Because FOXM1 phosphorylation has been shown to be catalyzed by cyclin-dependent kinases , and CDK2 expression is transcriptionally regulated by MITF , …
dan whitfield authorWeb11 aug. 2010 · MiTF phosphorylation was examined 1 hour after various doses of UVC radiation; as low as 1 mJ/cm 2 of radiation led to MiTF phosphorylation in c83-2C cells (Fig 1D). MiTF phosphorylation is via Erk1/2 mitogen-activated protein kinases (MAPK) and is required for its subsequent proteasome-dependent degradation. dan whitfield tampaWebA MITF gene alone produces nine differing MITF isoforms, all of which share exons 2-9. The expression of MITF occurs in melanocytes and comprises a basic domain for DNA … birthday wishes to granddaughter from grandmaWeb5 jun. 2024 · Furthermore, MITF activity is regulated at the post-transcriptional level mainly by phosphorylation . MITF may be phosphorylated by several kinases such as MAPK, p38, ribosomal S6 kinase (RSK), and GSK3β [7,11,34,35]. birthday wishes to grandmotherWebThe microphthalmia-associated transcription factor (Mitf) has emerged as an important model for gene regulation in eukaryotic organisms. In vertebrates, it regulates the … birthday wishes to manager in hindiWeb23 jan. 2024 · MITF phosphorylation is short term and happens immediately after allergic trigger, since longer exposure time may lead to ubiquitin-mediated degradation, as was … birthday wishes to hr managerWeb23 mrt. 2024 · The switch was ERK dependent, and the expression of the melanoma-specific transcription factor and oncogene MITF (melanoma-associated transcription factor) was decreased. ... As PIK3CA-E545K increases S6K1 and S6 phosphorylation in the AKT/mTOR pathway, inhibition of the S6K1 kinase could be used to revert the resistance . dan whitfield for senate