WebMay 13, 2024 · DDB1 is required for the expression of thermogenic genes in BAT. (a–c) RNA-seq analysis of the BAT of Ddb1-AKO and control littermates (12-week-old male). Each sample contained RNAs pooled from three mice of each genotype. (a) The DDB1-regulated genes are shown in a scatter plot with a fold change greater than 1.5. WebAug 17, 2024 · To recognize diverse substrates, DDB1-CUL4-RBX1 requires a type of substrate-specific receptor proteins known as DDB1 CUL4 associated factors (DCAF). More than 60 human proteins have been proposed as DCAFs ( Lee and Zhou, 2007 ) and …
DDB1 damage specific DNA binding protein 1 [ (human)]
WebDec 12, 2024 · Structural insights into DDA1 function as a core component of the CRL4-DDB1 ubiquitin ligase. Shabek et al. (2024) 1 more is a member of EMBL-EBI. Services. Research. Training. Industry. About us. EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SD, UK +44 (0)1223 49 44 44 ... WebVoltage-gated ClC-2 channels are essential for chloride homeostasis. Complete knockout of mouse ClC-2 leads to testicular degeneration and neuronal myelin vacuolation. Gain-of-function and loss-of-function mutations in the ClC-2-encoding human CLCN2 gene are linked to the genetic diseases aldosteronism and leukodystrophy, respectively. The … cm kvadratni u cm
Ddb1 Is Essential for the Expansion of CD4 - PubMed
As its name suggests, DDB1 was initially implicated in the process of a specific type of DNA repair known as nucleotide excision repair. Since then, researchers have found that DDB1 primarily functions as a core component of the CUL4A- and CUL4B-based E3 ubiquitin ligase complexes. DDB1 serves as a bridge … See more DNA damage-binding protein 1 is a protein that in humans is encoded by the DDB1 gene. See more The gene's position is on chromosome 11q12-q13. See more DDB1 has been shown to interact with Transcription initiation protein SPT3 homolog, GCN5L2, DDB2, CUL4A, CUL4B and See more The DDB1 gene encodes the large subunit of DNA damage-binding protein, a heterodimer composed of a large and a small ( See more • Chu G, Chang E (1988). "Xeroderma pigmentosum group E cells lack a nuclear factor that binds to damaged DNA". Science. 242 (4878): 564–7. doi:10.1126/science.3175673. PMID 3175673. • Lee TH, Elledge SJ, Butel JS (1995). "Hepatitis B virus X protein interacts with a probable cellular DNA repair protein" See more WebJul 30, 2015 · DNA damage-binding protein 1 (DDB1) is a large subunit of the heterodimeric DDB complex that recognizes DNA lesions and initiates the nucleotide excision repair process. DDB1 is also a component of the CUL4 E3 ligase complex involved in a broad spectrum of cellular processes by targeted ubiquitination of key regulators. Functions of … WebMay 15, 2007 · Function Acts both as a substrate recognition component of E3 ubiquitin-protein ligase complexes and as an atypical serine/threonine-protein kinase, playing key roles in various processes such as cell cycle, telomerase regulation and … tased